By Edited by: Daniel L. Purich, Daniel L. Purich
This ebook is an element A in a subseries entitled "Amino Acid Metabolism". subject matters partly A might be of fast curiosity to people who are commonly inquisitive about amino acid assimilation and metabolism. Investigators drawn to enzyme mechanism and law also will locate this quantity in particular invaluable.
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Extra resources for Amino Acid Metabolism, Part A, Volume 72, Advances in Enzymology and Related Areas of Molecular Biology
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Although there are obvious obstacles to surmount, this writer remains confident that the systematic remodeling of known ligases into polypeptide ligases will be fulfilled during my lifetime. V. Concluding Remarks ATP and other nucleoside-5'-triphosphates play a major role in facilitating catalysis by converting oxygen atoms into better leaving groups at physiologic pH. This can be accomplished by phosphorylation or nucleotidylation, followed by nucleophilic attack to release orthophosphate or a nucleoside-5'-monophosphate as the actual leaving group.
1990; Cooper, 1990). Balance studies across the whole liver gave either conflicting results or demonstrated no net glutamine turnover at all, favoring an early view in which the liver did not play a major role in glutamine metabolism, although the activities of glutamine metabolizing enzymes were found to be high. Later, a fundamental conceptional change in the field of hepatic glutamine metabolism was derived from the understanding of the unique regulatory properties of hepatic glutaminase, the discovery of hepatocyte heterogeneities in glutamine metabolism with metabolic interactions between differently localized subacinar hepatocyte populations, and the role of an intercellular cycling of glutamine in the liver acinus for the maintenance of whole body ammonia and bicarbonate homeostasis.
Amino Acid Metabolism, Part A, Volume 72, Advances in Enzymology and Related Areas of Molecular Biology by Edited by: Daniel L. Purich, Daniel L. Purich