By Gerd Plewig MD, Albert M. Kligman MD, PhD (auth.)
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Extra info for Acne: Morphogenesis and Treatment
J. Denn. 88,257-262 (1973). : Das Verhalten der Talgsekretion wiihrend der Behandlung der Acne mit Cyproteronacetat und Athinylostradiol. Arch. Derm. Forsch. 247,259-264 (1973). 37 Bacteriology For a long while acne was put down as a bacterial infection; scholars quarreled whether aerobes or anaerobes were the infectious agents. , redness, tenderness, and above all suppuration. Injection of cultured organisms even produced pustules. Correlatively, antibiotics were beneficial. " Only three kinds of organisms need be considered.
Effect of Temperature At body temperature sebum is a liquid. At surface temperature which might prevail in cold weather, say 25°C (skin temperature, not ambient temperature) it is semi-solid. Thus, the viscosity of sebum and its flow properties could be affected by external temperatures in the physiologic range. Heating the surface with an infra-red bulb will result in more sebum being collected by the cigarette paper method. This clearly makes sebum in the follicular reservoir more liquid causing it to flow out more swiftly.
As little as 5 mg of methyl testosterone will cause great and prompt enlargement in a prepubertal individual. In women the blood level of testosterone is about one-tenth that of men. Consequently, women produce less sebum, are less oily and suffer less from acne. The increase in sebum production when testosterone is given to adult females shows clearly that the glands are not being maximally stimulated. No increment is obtained in males, the glands already having responded to the extent determined by genetic factors.
Acne: Morphogenesis and Treatment by Gerd Plewig MD, Albert M. Kligman MD, PhD (auth.)